Neurocritical Care Consortia & Initiatives

A variety of joint efforts involving academic centers, industry, government, and private groups are underway to explore research and advance science related to brain injuries encountered in neurointensive care.  A summary list of major consortia and initiatives listed below.

Cardiac Arrest

The NCS formally endorses two cardiac arrest registries: the International Cardiac Arrest Registry (INTCAR) and Get With the Guidelines - Resuscitation (formerly NRCPR).  Both registries are resources to institutions involved in post-resuscitation care of cardiac arrest survivors, providing standardized data collection resources, individualized institutional feedback and data to participants, access to group data, and the opportunity to help improve survival for patients suffering cardiac arrest by improving the science behind our therapeutic options.

In 2009, the Hypothermia Network, a primarily northern European registry that includes what is currently the largest series of cardiac arrest survivors treated with therapeutic hypothermia, joined with the Neurocritical Care Society and European Cardiac Arrest Research Network to form the International Cardiac Arrest Registry (INTCAR). The organization is governed by European and North American Steering Committees. Stated aims of INTCAR are:

  • Gain a better understanding of the process of care and outcomes associated with cardiac arrest, which has traditionally been considered the most devastating and least treatable form of brain injury.
  • Promote the appropriate use of therapeutic hypothermia after cardiac arrest through a continuous update of clinical outcomes and process-of-care variables through a common worldwide registry.
  • To identify key areas for future research in the treatment of cardiac arrest.

Membership in INTCAR is free, and members are encouraged to enroll de-identified data on all cardiac arrest survivors hospitalized at their institution. A standardized, web-based data collection form allows for easy tracking of cardiac arrest outcomes from the institution, and access to global data from within the group is granted to members. INTCAR is supported by the Stig and Ragna Gorthon Foundation and the Scandinavian Society of Anaesthesiology and Intensive Care.

Learn more about INTCAR

Get With the Guidelines - Resuscitation is the world’s leading in-hospital resuscitation registry and has been collecting standardized data for over 10 years.  Get With the Guidelines - Resuscitation includes data from over 350 hospitals and 150,000 in-hospital cardiac arrest and medical emergency team events.

Get With the Guidelines - Resuscitation provides high-quality quarterly reports to member institutions that outline individual institutional performance, and show aggregate benchmark data for comparison.  It is governed by a scientific advisory board, with support and guidance from the American Heart Association.  A dedicated research task force provides oversight to data integrity, data cleaning, and all publications.

Get With the Guidelines - Resuscitation takes pride in the exceptional quality of its data elements, utilizing standardized operational definitions to help assure data quality between sites.  Data entry personnel undergo specific training and certification, and the data software has self-checks designed to notify the data entry person of missing or outlying responses.  Optional monthly teleconferences and an annual users meeting assure data integrity and provide users with clinical and scientific education.  Get With the Guidelines - Resuscitation ma

All Get With the Guidelines - Resuscitation participants may submit research requests based on aggregate data.  Among many publications, Get With the Guidelines - Resuscitation data has been published in medical journals such as JAMA, the New England Journal of Medicine, Pediatrics, Resuscitation and Critical Care Medicine.  They have been widely acknowledged by groups such as ILCOR, the Critical Care Society, and the Resuscitation Science Symposium.intains a clinical help line staffed by a nurse, and provides assistance with software and data transfer issues.  

Read More about NRCPR...

NETT Consortium

The Neurological Emergencies Treatment Trials (NETT) Network is a large network dedicated toward emergency issues.  The NETT is made up of 22 “Hub” institutions nationwide, each having at least three “Spoke” hospitals.  The NETT Network is interdisciplinary, including, but not limited to, emergency physicians, neurologists and neurosurgeons.



COSBID is a research interest group focused on the causes and consequences of spreading depolarizations as a pathologic mechanism in neurologic diseases. The group started as a clinical research collaboration, and today those efforts have grown into several single and multi-center studies of brain injury resulting from trauma and various types of stroke. 


CDE Initiatives of NINDS


The National Institute of Neurological Disorders and Stroke (NINDS) and several Co-sponsoring Federal agencies have the common mission of developing data standards for clinical research. Through the efforts of subject-specific working groups, topic-driven data elements have been created. The first set of CDEs were developed in 2010 and were well-suited for hospital-based studies of acute TBI in adults. To broaden the utility of the TBI CDEs, experts were asked to update the recommendations to make them relevant to all ages, injury severity, and phases of recovery.