Investing in Clinical Neurocritical Care Research (INCLINE) Grant 2018

Funding Opportunity Announcement (FOA):

INvesting in CLINical Neurocritical CarE Research (INCLINE) grant:

The Neurocritical Care Society (NCS) has promoted research in neurocritical care through the creation of the Neurocritical Care Research Network (NCRN), and through funded research fellowships. The NCS announces a new research grant opportunity for members to foster promising and innovative, collaborative, multi-center research. This FOA is directed towards improving clinical outcomes in neuroscience critical care through clinical or translational research strategies. The scope of this FOA is to provide one (1) year of funding for collaborative multi-center pilot studies in neurocritical care that will enable the awardees to develop preliminary data to submit a formal proposal to national funding agencies such as the NIH, Department of Defense, PCORI, etc.

Research Objectives: 

The objectives of this FOA are to promote creative and collaborative, multi-center research to improve clinical outcomes in neuroscience critical care. The NCS has adopted a leadership position in nurturing enhanced quality of care through innovative care strategies, translational science, use of technology, development of evidence-based medicine, study of point prevalence models of care, population science, and many others. Though there is a distinct clinical focus to the objectives of this FOA, translational studies that have direct application to clinical care will broadly remain under its scope. The objective is to encourage collaborative proposals which serve to create a longitudinal pipeline of research. Under this FOA, the NCS wishes to foster scientific projects that will be competitive for future funding from NIH, DOD, PCORI or similar agencies. The NCS desires to promote team science, and enhance the rigor and visibility of neuroscience intensive care among existing and future team science collaborations. Therefore, preference will be granted to proposals that may be conducted as multi-center studies within the NCRN, but participation in other national and/or international networks will be permissible.


Types of studies include, but are not limited to:

1) Point prevalence studies which describe a fundamental clinical care intervention and/or practice in a neuroscience intensive care unit

2) Informatics studies, which describe the fundamental aspects of data acquisition, monitoring, storage, analysis or processing in the neuroscience intensive, care unit.

3) Translational studies, which foster novel treatment for common diseases seen in the neuroscience intensive care unit, with emphasis on proof of concept in a targeted patient population, conducted in a small multicenter study.

4) Pilot observational studies to determine feasibility of conducting a future observational or interventional study in the neuroscience intensive care unit.

5) Pilot trials to determine feasibility of conducting a future trial in the neuroscience intensive care unit.

6) Multidisciplinary process-oriented research that directly impact patient-centered care and outcomes

7) Population studies that will directly enhance the care of neurocritically ill patients.

Collaboration Objectives that are desired for this application:

Facilitate a future multi-center center approach to enhance scientific rigor and generalizability.

2) Enhance the opportunities for the NCRN to conduct early-phase studies.

3) Create data formats, which could be used as models for national networks.

The following will not be considered in this FOA:

  • Retrospective studies
  • Focused self-reported surveys
  • Mechanistic physiological studies in a laboratory setting
  • Computational Algorithm development in a laboratory setting using preexisting data
  • Infrastructure or registry development proposals

The award will be up to $100,000. 10% indirect costs will be permitted if a necessary requirement of the institution. A single award will be issued each year. The award must be spent within period of the award notice, with no-cost extensions permissible without appropriate justification.

Budget Constraints: The budget is constrained to the following:

  • $15,000 maximum salary support for the PI
  • Patient enrollment reimbursement for study related costs
  • $10,000 for equipment
  • $5,000 for travel to facilitate multi-center study

Eligibility Criteria:

The applicant must be an active NCS member in good standing. Members in all career stages are eligible to apply as long as the study requirements described in the FOA are met. For purposes of career development, early career investigators and trainees are encouraged to apply for a separate NCS Research Fellowship Training Award RFA. Healthcare professionals providing neurocritical care in different roles, including physicians, advanced practitioners, nurses, pharmacists, and PhD-scientists are encouraged to apply. 

Letter of Intent (LOI) Instructions

Applicants are required to submit a “Letter of Intent (LOI) to Submit an Application” by 2/28/2018. Letters of Intent will be reviewed by members of the NCS grants subcommittee in order to ensure that the proposed project fits appropriately within the INCLINE grant directive, and to plan for appropriate expertise in the peer review panel. Upon review of the LOI, qualified projects will be invited by 4/1/2018 to submit a full grant application, which will be due on 6/1/2018.   

Please use the following formatting guidelines for LOI submission:

1. The LOI must adhere to the following format:

a. Font size must be at least 11-point Arial font
b. Margins must be at least one inch in all directions
c. Line spacing must not exceed six lines of text per vertical inch
d. Page size must be U.S. letter (i.e., 8.5 inches × 11 inches).

2. The LOI is limited to two (2) pages

On Page 1, provide only the following information: proposal title, names, professional titles, departments, institutions, and e-mail addresses of the lead project investigator (PI), and all collaborating investigators (Co-Is).

On Page 2 (one page only), include:

  • A descriptive title
  • Rationale
  • Overall hypothesis or goal
  • Specific aims
  • Approach
  • Potential impact and expected outcomes.

3. Please also attach NIH-format biosketches of the PI(s) and Co-Is, using the most updated version from 9/2017 (, limited to 4 pages per biosketch.

4. NCS will only accept LOI-materials submitted in the portable document format (PDF). Please combine all data into one single PDF file.  Attach the PDF to an e-mail to with “Letter of Intent, INCLINE Grant” in the subject heading.

Please direct any questions to:

Tissy Greene
Paul Vespa
Javier Provencio
Susanne Muehlschlegel
Chethan Rao