COVID-19 Research Opportunities

COVID-19 RESEARCH OPPORTUNITIES

Help determine the impact of COVID-19 on neurocritical care by participating in the following research. We have developed an international collaborative using common data elements for these studies. Our collaborative includes registered sites from 15 countries around the world, and partnerships with other professional organizations for harmonization of common data elements across initiatives. If you are part of a professional organization interested in collaborating with these efforts, please contact info@neurocriticalcare.org.

If you are an investigator who would like to register your site, please read the descriptions below and fill out the corresponding surveys to indicate your interest.

NCC COVID 19 OUTCOMES: This study is a prospective cohort observational study to determine the impact of COVID 19 crisis on resource allocation and outcomes of ICU patients with acute neurological injury who require routine care and are not necessarily COVID 19 positive. The study will evaluate mortality and functional outcomes at hospital discharge and 90 days among critically ill, neurologically impaired patients admitted during the COVID 19 crisis period. Participating sites have the option to also compare those outcomes to a historical control group who were treated prior to the COVID 19 crisis. 

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NCC COVID 19 MANIFESTATIONS: This study is a prospective observational cohort study to document prevalence and severity of neurological symptoms among patients with confirmed or suspected novel coronavirus (COVID 19). This study contains common data elements that all sites are requested to obtain (Tier 1 data), as well as supplemental data elements that are optional for sites to obtain retrospectively based on time and resources. This study will also offer optional addendums to investigate Tier 2 and Tier 3 strategies, such as more invasive blood and tissue sampling, based on local resources. 

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NCC COVID 19 MANIFESTATIONS IN PEDIATRIC PATIENTS: This study is an observational cohort study to document prevalence and severity of neurological symptoms among patients younger than 18 years old admitted to the hospital with confirmed or presumed novel coronavirus (COVID 19). This study contains common data elements that all sites are requested to obtain (Tier 1 data). Tier 1 data are generally obtainable from electronic medical records and similar sources, under an IRB protocol allowing waiver of consent. Interested sites may also collect Tier 2 data such as standardized outcome measures at a later time point (~ 1 month after hospital discharge). A second IRB for tier 2 data would require informed consent, as would the process of data sharing outside the institution. We will provide IRB templates for both Tier 1 and 2 as well as a Case Report Form upon registration of your unique site.

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Please note: All registered sites will receive access to study protocols and case report forms (CRF). It is the responsibility of each study site and principal investigator to submit these documents to their institutional officials to obtain the required ethical and organizational approvals before collecting any data.