Investing in Clinical Neurocritical Care Research (INCLINE)


The purpose of the INCLINE grant is allow investigators to develop pilot research strategies that enhance clinical care in the neuroscience intensive care unit. The scope of this RFA is to provide 1 year of funding to support pilot studies that will enable the awardee to successfully compete for federal funding such as from the NIH, Department of Defense, or PCORI.

Research Objectives

The INCLINE grant is designed to promote creative and collaborative research to improve clinical outcomes in neuroscience critical care. In 2016, the leaders of the Neurocritical Care Research Central (NCRC) and the Neurocritical Care Research Network (NCRN) identified important gaps in our research portfolio and envisioned an approach to begin to working constructively on these gaps.  The mission-critical topic that has been embraced after much deliberation is “Curing Coma.” The goal is to develop an understanding of the mechanisms that underlie coma in critically ill patients and discover preventive and novel therapeutic measures. Moreover, this is a broad endeavor that should eventually lead to the intersections between scientific discovery, implementation, education and advocacy that are necessary to fundamentally change the care of patients with acute disorders of consciousness.  To this end, the INCLINE grant will focus on facilitating collaborative research to address the mission of the “Curing Coma® Campaign” and proposals enhancing this line of research will be viewed most favorably.

It should be noted that coma-related research is broad and includes conditions such as delirium, and encephalopathy which lie along the spectrum of disorders of consciousness, as well as a diverse group of etiologies of disordered consciousness.  There are many areas of research within Neurocritical Care that are within the domain of the “Curing Coma” mission.  For specific questions about the Curing Coma Campaign as it relates to this RFA, please contact Claude Hemphill (, or DaiWai Olson (

The INCLINE RFA has a distinct clinical focus; however, translational science with direct application to clinical care is also broadly within the scope. NCS wishes to foster longitudinally meaningful scientific projects that will be competitive for future funding from NIH, DOD or similar; and which serve to create a pipeline of research and enhance one of more scientific lines of research. NCS desires to enhance collaborative research and team science, and enhance the rigor and visibility of neuroscience intensive care among existing and future team science collaborations.

Types of studies include, but are not limited to:

  • Point prevalence studies, which describe a fundamental clinical care intervention and/or practice in the neuroscience intensive care unit.
  • Informatics/data analytics studies, which describe the fundamental aspects of data acquisition, monitoring, storage, analysis or processing in the neuroscience intensive care unit.
  • Pilot clinical trials which foster novel treatment for common diseases seen in the neuroscience intensive care unit using translational approach, with emphasis on proof of concept in a targeted patient population, conducted in a small multicenter study.
  • Pilot observational studies, which determine feasibility of conducting a future observational or interventional study in the neuroscience intensive care unit.
  • Multidisciplinary process-oriented research, which directly impact patient-centered care and outcomes.
  • Population health studies, which will directly enhance the care of neurocritically ill patients.


Deadline for Letter of Intent: May 31, 2022

Invitations for Full Applications: June 6, 2022

Deadline for Full application (if invited after letter of intent): June 24, 2022

Download the full RFA here. 

The recipient of the 2022 INCLINE Grant will be announced at the 19th Annual Meeting in October. 

For all questions related to this RFA, please email: