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Critically Ill Patients Treated for Chimeric Antigen Receptor-Related Toxicity

Critical Care Medicine (07/02/21) DOI: 10.1097/CCM.0000000000005149 Gutierrez, Cristina; Brown, Anne Rain T.; May, Heather P.; et al. https://journals.lww.com/ccmjournal/Abstract/9000/Critically Ill Patients Treated for Chimeric.95168.aspx In a new study, U.S. researchers report a...


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Effect of Continuous Infusion of Hypertonic Saline vs Standard Care on 6-Month Neurological Outcomes in Patients with Traumatic Brain Injury

Journal of the American Medical Association (05/25/21) DOI: 10.1001/jama.2021.5561 Roquilly, Antoine; Moyer, Jean Denis; Huet, Olivier; et al. https://jamanetwork.com/journals/jama/article-abstract/2780326 For the COBI clinical trial, researchers compared outcomes in adults with...


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Second Intravenous Immunoglobulin Dose in Patients with Guillain-Barré Syndrome with Poor Prognosis (SID-GBS): A Double-Blind, Randomised, Placebo-Controlled Trial

The Lancet Neurology (04/01/21) DOI: 10.1016/S1474-4422(20)30494-4 Walgaard, Christa; Jacobs, Bart C; Lingsma, Hester F; et al. https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(20)30494-4/fulltext New research finds no benefit but a risk of serious adverse events from a...


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Association Between Intracerebral Hemorrhage and Subsequent Arterial Ischemic Events in Participants From 4 Population-Based Cohort Studies

JAMA Neurology (05/03/21) DOI: 10.1001/jamaneurol.2021.0925 Murthy, Santosh B.; Zhang, Cenai; Diaz, Ivan; et al. https://jamanetwork.com/journals/jamaneurology/article-abstract/2779594 Intracerebral hemorrhage correlated with a greater risk of ischemic stroke and myocardial infarction,...


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Global Incidence of Neurological Manifestations Among Patients Hospitalized With COVID-19—A Report for the GCS-NeuroCOVID Consortium and the ENERGY Consortium

JAMA Network Open (05/11/21) DOI: 10.1001/jamanetworkopen.2021.12131 Chou, Sherry H.-Y.; Beghi, Ettore; Helbok, Raimund; et al. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2779759 Neurological manifestations are common among patients hospitalized with COVID-19,...


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NEWS: Initiation of statin after ICH but not continuation may lead to worse perihematomal edema: results of a single-center study

Reviewed by Sanjeev Sivakumar, MD Read the Article* *Article access requires subscription/login Impact of Statins on Hematoma, Edema, Seizures, Vascular Events, and Functional Recovery After Intracerebral Hemorrhage. Maximilian I. Sprügel, Joji B. Kuramatsu et al. Stroke 2021 Mar...


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NEWS: Andexanet alpha and four-factor prothrombin complex concentrate show similar rates of ICH stability on imaging when used for reversing factor Xa inhibitors.

Reviewed by Shannon Hextrum, MD Read the Article Ammar AA, Ammar MA, Owusu KA, et al. Andexanet Alfa Versus 4-Factor Prothrombin Complex Concentrate for Reversal of Factor Xa Inhibitors in Intracranial Hemorrhage [published online ahead of print, 2021 Jan 6]. Neurocrit Care . 2021;10...


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NEWS: In decompressive hemicraniectomy for malignant cerebral infarctions, ICPs >10 mmHg may be predictive of patient mortality

Hernández-Durán S, Meinen L, Rohde V, von der Brelie C. Invasive Monitoring of Intracranial Pressure After Decompressive Craniectomy in Malignant Stroke. Stroke . 2021 Jan;52(2):707-711. doi: 10.1161/STROKEAHA.120.032390. Epub 2020 Dec 4. Reviewed by Shannon Hextrum, MD READ THE...


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NEWS: Interpretation of Brain Tissue Oxygen – Probe Location Matters!

Lindner A, Rass V, Ianosi BA, et al. The Importance of PbtO2 Probe Location for Data Interpretation in Patients with Intracerebral Hemorrhage. Neurocritical Care . 2020 Sep 11:1-0. Reviewed by Wazim Mohamed, MD Read the Article Background : Secondary brain injury after...


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6-Month Neurological and Psychiatric Outcomes in 236 379 Survivors of COVID-19: A Retrospective Cohort Study Using Electronic Health Records

The Lancet Psychiatry (04/06/21) DOI: 10.1016/S2215-0366(21)00084-5 Taquet, Maxime; Geddes, John R.; Husain, Masud; et al. https://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(21)00084-5/fulltext Approximately a third of people diagnosed with COVID-19 exhibited longer term...