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Andexanet Alfa Versus 4-Factor Prothrombin Complex Concentrate for Reversal of Factor Xa Inhibitors in Intracranial Hemorrhage

By Abdalla A. Ammar, Mahmoud A. Ammar, Kent A. Owusu, Stacy C. Brown, Firas Kaddouh, Aladine A. Elsamadicy MD, Julián N. Acosta & Guido J. Falcone First Online: 06 January 2021 Background/Objective There are limited data on the risks and benefits of using andexanet alfa (AA) in...


Blog Entry
High Serum Soluble Fas Ligand Levels in Non-survivor Traumatic Brain Injury Patients

By Leonardo Lorente, María M. Martín, Antonia Pérez-Cejas, Agustín F. González-Rivero, Luis Ramos-Gómez, Jordi Solé-Violán, Juan J. Cáceres, Judith Cabrera, Andrea Alvarez-Castillo, Carmen Ferrer-Moure & Alejandro Jiménez First Online: 06 January 2021 Purpose Soluble Fas Ligand ...


Blog Entry
Is the CT Blend Sign Composed of Two Parts of Blood with Different Age?

By Yinghui Li, Siying Ren, Likun Wang, Yuanhong Mao, Guofeng Wu, Qi Li & Zhouping Tang First Online: 06 January 2021 Background Blend sign on initial computed tomography (CT) is associated with poor outcome in patients with intracerebral hemorrhage (ICH). However, the mechanisms...


Blog Entry
Failure Mode and Effect Analysis: Engineering Safer Neurocritical Care Transitions

By Priyanka Chilakamarri, Emily B. Finn, John Sather, Kevin N. Sheth, Charles Matouk, Vivek Parwani, Andrew Ulrich, Melissa Davis, Laura Pham, Sarwat I. Chaudhry & Arjun K. Venkatesh First Online : 05 January 2021 Background/objective Inter-hospital patient transfers for...


Blog Entry
Pterygopalatine Fossa Blockade as Novel, Narcotic-Sparing Treatment for Headache in Patients with Spontaneous Subarachnoid Hemorrhage

By Cameron R. Smith, W. Christopher Fox, Christopher P. Robinson, Cynthia Garvan, Marc-Alain Babi, Michael A. Pizzi, Erica Lobmeyer, Alberto Bursian, Carolina B. Maciel & Katharina M. Busl First Online: 05 January 2021 Background Severe headache is a hallmark clinical feature of...


Blog Entry
Targeted Temperature Management Suppresses Hypoxia-Inducible Factor-1α and Vascular Endothelial Growth Factor Expression in a Pig Model of Cardiac Arrest

By Jiebin Li, Chunsheng Li, Wei Yuan, Junyuan Wu, Jie Li, Zhenhua Li & Yongzhen Zhao First Online : 05 January 2021 Background The hypoxia-inducible factor-1α (HIF-1α)/vascular endothelial growth factor (VEGF)/VEGF receptor subtype 2 (VEGFR-2) pathway has been implicated in...


Blog Entry
The Association Between Arterial Oxygen Level and Outcome in Neurocritically Ill Patients is not Affected by Blood Pressure

By Jaana Humaloja, Markus B. Skrifvars, Rahul Raj, Erika Wilkman, Pirkka T. Pekkarinen, Stepani Bendel, Matti Reinikainen & Erik Litonius First Online : 05 January 2021 Background In neurocritically ill patients, one early mechanism behind secondary brain injury is low systemic...


Blog Entry
Sustained Low-Efficiency Dialysis is Associated with Worsening Cerebral Edema and Outcomes in Intracerebral Hemorrhage

By Alireza Shirazian, Andres F. Peralta-Cuervo, Maria P. Aguilera-Pena, Louis Cannizzaro, Vi Tran, Doan Nguyen & Ifeanyi Iwuchukwu First Online: 05 January 2021 Background/Objectives We postulated that renal replacement therapy (RRT) in ICH patients with advanced chronic kidney...


Blog Entry
Automated Pupillometry Identifies Absence of Intracranial Pressure Elevation in Intracerebral Hemorrhage Patients

By Antje Giede-Jeppe, Maximilian I. Sprügel, Hagen B. Huttner, Matthias Borutta, Joji B. Kuramatsu, Philip Hoelter, Tobias Engelhorn, Stefan Schwab & Julia Koehn First Online : 24 December 2020 Introduction Although automated pupillometry is increasingly used in critical care settings,...


Blog Entry
Individualized Brain Tissue Oxygen-Monitoring Probe Placement Helps to Guide Therapy and Optimizes Outcome in Neurocritical Care

By Levin Häni, Mario D. Ropelato, Franca Wagner, Andreas Nowacki, Nicole Söll, Matthias Haenggi, Andreas Raabe & Werner J. Z’Graggen First Online: 16 December 2020 Background/Objective In order to monitor tissue oxygenation in patients with acute neurological disorders, probes...