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The Curing Coma Campaign: Framing Initial Scientific Challenges—Proceedings of the First Curing Coma Campaign Scientific Advisory Council Meeting

By J. Javier Provencio, J. Claude Hemphill, et. al. on behalf of the Neurocritical Care Society Curing Coma Campaign First Online: 23 June 2020 Coma and disordered consciousness are common manifestations of acute neurological conditions and are among the most pervasive and challenging...


Blog Entry
Reply to “Key Points to Consider When Evaluating Andexxa for Formulary Addition”

By Charles E. Mahan First Online: 22 June 2020 Dear Editor, I read with interest the article evaluating ANDEXXA (coagulation factor Xa [recombinant], inactivated-zhzo; andexanet alfa [US-adopted name]) for formulary addition by Peled et al. [1]. However, many statements in the publication...


Blog Entry
Determining Optimal Mean Arterial Pressure After Cardiac Arrest: A Systematic Review

By Kiran J. K. Rikhraj, Michael D. Wood, Ryan L. Hoiland, Sharanjit Thiara, Donald E. G. Griesdale & Mypinder S. Sekhon First Online: 22 June 2020 Abstract The use of cerebral autoregulation monitoring to identify patient-specific optimal mean arterial pressure (MAPOPT) has emerged...


Blog Entry
Incidence of Antithrombin Deficiency and Anti-Cardiolipin Antibodies After Severe Traumatic Brain Injury: A Prospective Cohort Study

By Shankar Kalgudi & Kwok M. Ho First Online: 18 June 2020 Background Animal studies suggested that cerebral mitochondrial cardiolipin phospholipids were released after severe traumatic brain injury (TBI), contributing to the pathogenesis of thromboembolism. Objectives To...


Blog Entry
Low Triglyceride Levels are Associated with Unfavorable Outcomes in Patients with Spontaneous Intracerebral Hemorrhage

By Qian Liu, Wenjuan Zhao, Yonghong Xing, Yan Hong & Guanen Zhou First Online: 18 June 2020 Background and Aims The relationship between serum lipid level and clinical outcome after spontaneous intracerebral hemorrhage (ICH) remains controversial. We sought to evaluate the...


Blog Entry
Catheter-Associated Urinary Tract Infection (CAUTI) in the NeuroICU: Identification of Risk Factors and Time-to-CAUTI Using a Case–Control Design

By Karen Perrin, Anu Vats, Aater Qureshi, Jeannette Hester, Angela Larson, Alfeil Felipe, Andressa Sleiman, Jacqueline Baron-Lee & Katharina Busl First Online: 17 June 2020 Background/Objective Catheter-associated urinary tract infections (CAUTIs) account for 25% of all hospital...


Blog Entry
Allied Muslim Healthcare Professional Perspectives on Death by Neurologic Criteria

By Ariane Lewis, Elizabeth Kitamura & Aasim I. Padela First Online: 17 June 2020 Background We sought to evaluate how Muslim allied healthcare professionals view death by neurologic criteria (DNC). Methods We recruited participants from two listservs of Muslim American health...


Blog Entry
The State of Autoregulation

By Stefan Wolf First Online: 16 June 2020 Cerebral autoregulation is a well-identified therapeutic target after traumatic brain injury (TBI) in current guidelines and recommendations [1,2,3]. It represents an independent predictor for worse outcome, besides demographic and injury severity...


Blog Entry
Acute and Long-Term Outcomes of Lateralized Rhythmic Delta Activity (LRDA) Versus Lateralized Periodic Discharges (LPDs) in Critically Ill Patients

By Khalil S. Husari, Emily L. Johnson & Eva K. Ritzl First Online: 15 June 2020 Background To assess the acute and long-term outcomes for patients with lateralized rhythmic delta activity (LRDA) compared to patients with lateralized periodic discharges (LPDs). Methods A single...


Blog Entry
Assessment of Dynamic Intracranial Compliance in Children with Severe Traumatic Brain Injury: Proof-of-Concept

By Michael S. Wolf, Jaskaran Rakkar, Christopher M. Horvat, Dennis W. Simon, Patrick M. Kochanek, Gilles Clermont & Robert S. B. Clark First Online: 15 June 2020 Background and Aims Intracranial compliance refers to the relationship between a change in intracranial volume and the...